KONJUGATE VON TC KOMPLEXEN UND ZIELGERICHTETE EINHEITEN UND IHRE VERWENDUNG IN NMR-DIAGNOSTIK

The present invention relates to improved Tc radiometal complex compositions of aza-diaminedioxime ligands, together with radiopharmaceutical preparations containing them, and kits for the preparation of the radiopharmaceuticals. The technetium metal complexation chemistry of aza-diaminedioxime-targ...

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Bibliographic Details
Main Authors BARNETT, DAVID JONATHAN, LEWIS, JOANNE SARAH, BRAUERS, GEORG, WADSWORTH, HARRY JOHN, FARRAR, GILLIAN
Format Patent
LanguageGerman
Published 15.08.2008
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to improved Tc radiometal complex compositions of aza-diaminedioxime ligands, together with radiopharmaceutical preparations containing them, and kits for the preparation of the radiopharmaceuticals. The technetium metal complexation chemistry of aza-diaminedioxime-targeting molecule chelator conjugates is shown to give rise to a multiplicity of technetium species. The present invention provides an improved aza-diaminedioxime conjugate technetium metal complex composition in which the presence of the less desirable technetium species is suppressed.
Bibliography:Application Number: AT20030772392T