CYCLODEXTRINE TRAGENDE BIOLOGISCHE MATERIALIEN MIT VERBESSERTEN ABSORPTIONSEIGENSCHAFTEN ZUR PROGRESSIVEN UND VERZÖGERTEN FREISETZUNG VON THERAPEUTISCHEN MOLEKÜLEN

A method for preparing a biomaterial containing at least one bioactive molecule from a base biomaterial, comprising the following successive operations carried out on the base biomaterial: a) application of a solid mixture of: cyclodextrin(s) and/or cyclodextrin derivative(s) and/or cyclodextrin inc...

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Main Authors HAULON, STEPHAN, DELCOURT-DEBRUYNE, ELISABETH, HILDEBRAND, HARTMUT, BOSCHIN, FRANCOIS, MARTEL, BERNARD, MORCELLET, MICHEL, BLANAIN, NICOLAS
Format Patent
LanguageGerman
Published 15.06.2008
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Summary:A method for preparing a biomaterial containing at least one bioactive molecule from a base biomaterial, comprising the following successive operations carried out on the base biomaterial: a) application of a solid mixture of: cyclodextrin(s) and/or cyclodextrin derivative(s) and/or cyclodextrin inclusion complex(es) and/or cyclodextrin derivative inclusion complex(es), at least one poly(carboxylic) acid, and optionally a catalyst; b) heating at a temperature between 100° C. and 200° C. for a period of 1 to 60 minutes; c) washing with water; d) drying, wherein at least one bioactive agent is incorporated in the biomaterial by impregnation of the biomaterial after the drying step in a concentrated solution of the bioactive agent.
Bibliography:Application Number: AT20050817573T