OPTISCH AKTIVE QUINOLIN-CARBONSÄURE-DERIVATE MIT EINEM 7-PYRROLIDIN-SUBSTITUENTEN, DER DIE OPTISCHE AKTIVITÄT VERURSACHT UND EIN VERFAHREN ZU SEINER HERSTELLUNG

The present invention relates to optically active quinoline carboxylic acid derivatives, their pharmaceutically acceptable salts, their solvates, and a process for the preparation thereof. More specifically, the present invention relates to optically active)quinoline carboxylic acid derivatives cont...

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Main Authors CHOI, DONG RACK, JIN, YOON HO, YOON, SUNG JUNE, SHIN, JUNG HAN, LEE, CHI WOO, LEE, JIN SOO, YANG, WANG YONG, CHUNG, YONG HO, KIM, IK HOE, KIM, NAM,DOO, SONG, WAN JIN
Format Patent
LanguageGerman
Published 15.01.2008
Subjects
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to optically active quinoline carboxylic acid derivatives, their pharmaceutically acceptable salts, their solvates, and a process for the preparation thereof. More specifically, the present invention relates to optically active)quinoline carboxylic acid derivatives containing 4-aminomethyl-4-methyl-3-(Z)-alkoxyiminopyrrolidine substituents causing optical activity at the 7-position of the quinolone nuclei. As the compounds of the present invention have superior antibacterial activity and pharmacokinetic profiles to their enantiomers, their racemates and conventional antibacterial agents, with nearly no phototoxicity, the compounds of this invention are useful for antibacterial agents.
Bibliography:Application Number: AT20000927899T