VERFAHREN ZUR HERSTELLUNG VON AMORPHEM ATORVASTATIN KALZIUM

The invention relates to a process for the preparation of amorphous atorvastatin calcium by recrystallization of crude atorvastatin from an organic solvent which comprises dissolving crude amorphous atorvastatin calcium in a lower alkanol containing 2-4 carbon atoms or a mixture of such alkanols und...

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Main Authors RATKAI, ZOLTAN, SIMIG, GYULA, BALAZS, LASZLO, KOTAY NAGY, PETER, NAGY, KALMAN, GREFF, ZOLTAN, SZENT KIRALLYI, ZSUZSA, DOMAN, IMRE, BARTHA, FERENC, VERECZKEYNE DONATH, GYOERGYI, BARKOCZY, JOZSEF, SERES, PETER
Format Patent
LanguageGerman
Published 15.12.2006
Edition7
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Summary:The invention relates to a process for the preparation of amorphous atorvastatin calcium by recrystallization of crude atorvastatin from an organic solvent which comprises dissolving crude amorphous atorvastatin calcium in a lower alkanol containing 2-4 carbon atoms or a mixture of such alkanols under heating and isolating the amorphous atorvastatin calcium precipitated after cooling. The atorvastatin calcium obtained is a known valuable agent useful in treating hyperlipidemia and hypercholesterolemia.
Bibliography:Application Number: AT20000973115T