SUBSTITUIERTE N-PHENYL-2-HYDROXY-2-METHYL-3,3,3- TRIFLUORPROPANAMID-DERIVATIVE ZUR ERHÖHUNG DER PYRUVATDEHYDROGENASEAKTIVITÄT

A compound of formula (I) wherein: n is 1 or 2; R is chloro, fluoro, bromo, methyl or methoxy; R is as defined within; R is as defined within; and R is hydrogen or fluoro; or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof is described. The use of compounds of formula (I)...

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Bibliographic Details
Main Authors NOWAK, THORSTEN, BUTLIN, ROGER JOHN, BURROWS, JEREMY NICHOLAS, PEASE, JANET ELIZABETH, BLOCK, MICHAEL HOWARD
Format Patent
LanguageGerman
Published 15.04.2004
Edition7
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A compound of formula (I) wherein: n is 1 or 2; R is chloro, fluoro, bromo, methyl or methoxy; R is as defined within; R is as defined within; and R is hydrogen or fluoro; or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof is described. The use of compounds of formula (I) in the production of an elevation of PDH activity in a warm-blooded animal such as a human being are also described. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are detailed.
Bibliography:Application Number: AT20000956672T