BENZO(5,6)CYCLOHEPTA(1,2B)PYRIDINE DERIVATE ANWENDBAR ALS FARNESYL PROTEIN TRANSFERASE INHIBITOREN

Novel compounds of formula (1.0) or a pharmaceutically acceptable salt or solvate thereof, wherein: a represents N or NO<->; R and R are the same or different and each represents halo; R and R are the same or different and each is selected from H and halo, provided that at least one of R and R...

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Bibliographic Details
Main Authors SAKSENA, ANIL, K, COOPER, ALAN, B, DOLL, RONALD, J, GIRIJAVALLABHAN, VIYYOOR, M
Format Patent
LanguageGerman
Published 15.09.2003
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Novel compounds of formula (1.0) or a pharmaceutically acceptable salt or solvate thereof, wherein: a represents N or NO<->; R and R are the same or different and each represents halo; R and R are the same or different and each is selected from H and halo, provided that at least one of R and R is H; T is a substituent selected from SO2 R or (A); Z is O or S; n is zero or an integer from 1 to 6; R is alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, heterocycloalkyl, or N(R )2; R is H, alkyl, aryl, heteroaryl or cycloalkyl. Also disclosed are methods of inhibiting farnesyl protein transferase and methods for treating tumor cells.
Bibliography:Application Number: AT19980926277T