THIENYL-, FURYL-, PYRROLYL- UND BIPHENYLSULFONAMIDE UND DERIVATE ZUR MODULATION DER ENDOTHELIN-AKTIVITÄT

Biphenylsufonamides of the following formula and methods for modulating or altering the activity of the endothelin family of peptides are provided. The sulfonamides may be used for inhibiting the binding of an endothelin peptide to an endothelin receptor by contacting the receptor with the sulfonami...

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Main Authors KOIS, ADAM, CHAN, MING, FAI, BALAJI, VITUKUDI, NARAYANAIYENGAR, VERNER, ERIK, JOEL, KOGAN, TIMOTHY, WU, CHENGDE, CASTILLO, ROSARIO, SILVERSTRE, YALAMOORI, VENKATACHALAPATHI, RAJU, BORE, GOWDA
Format Patent
LanguageGerman
Published 15.07.2003
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Biphenylsufonamides of the following formula and methods for modulating or altering the activity of the endothelin family of peptides are provided. The sulfonamides may be used for inhibiting the binding of an endothelin peptide to an endothelin receptor by contacting the receptor with the sulfonamide or a pharmaceutically acceptable salt, acid or ester thereof, wherein Ar is and wherein Ar , R and R are as defined herein.m
Bibliography:Application Number: AT19960912600T