VERFAHREN ZUR SELEKTIVEN HERSTELLUNG VON Z- ISOMEREN VON 3-(2-SUBSTITUIERTES VINYL)CEPHALOSPORINEN

Z-Isomers of compounds of general formula (IV): Äwherein R is 2-(2-N-protected aminothiazol-4-yl)-2-alkoxyiminoacetyl or the like, R is hydrogen or the like; R is hydrogen, a carboxyl-protecting group or the like; and R is alkyl or the likeÜ can be prepared at high selectivities and in high yields b...

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Bibliographic Details
Main Authors SUKEGAWA MASAMICHI, IWASAWA HIROYUKI, MURAI YASUSHI, IINUMA KATSUHARU, OKADA YUMIKO, WATANABE TATSUO
Format Patent
LanguageGerman
Published 15.08.2002
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Z-Isomers of compounds of general formula (IV): Äwherein R is 2-(2-N-protected aminothiazol-4-yl)-2-alkoxyiminoacetyl or the like, R is hydrogen or the like; R is hydrogen, a carboxyl-protecting group or the like; and R is alkyl or the likeÜ can be prepared at high selectivities and in high yields by reacting a compound of general formula (I): Äwherein R , R and R are each as defined above; and R is aryl or the likeÜ with a 4-substituted or -unsubstituted thiazole-5-carbaldehyde in a mixed solvent comprising a chlorinated hydrocarbon and a lower alkanol at a temperature of as low as +5 DEG C or below.
Bibliography:Application Number: AT19980929666T