POLYMERKONJUGIERTE MALONSÄUREDERIVATE UND DEREN VERWENDUNG ALS ARZNEITMITTEL UND ALS DIAGNOSTIKA

• Main Authors: KRETZSCHMAR, GERHARD, BARTNIK, ECKART, SCHMIDT, WOLFGANG, TOEPFER, ALEXANDER, HOERSCH, BRIGITTE
• Format: Patent
• Language: German
• Published: 15.08.2002
• Edition: 7
• Subjects: CHEMISTRY; COMPOSITIONS BASED THEREON; DERIVATIVES THEREOF; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; ORGANIC MACROMOLECULAR COMPOUNDS; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SUGARS; TESTING; THEIR PREPARATION OR CHEMICAL WORKING-UP

Cpds. of formula (I) are new, with the exception of sialyl Lewis-X and -A, and derivs. of these which contain a N3, NH2 or OH substit. in place of a N-acetyl gp., or contain glycerin in place of fucose: R , R = H, CH2X or CH2O(CH2)mX ; or R +R = a six-membered substd. carbo- or hetero-cycle; R = O, S, H or CH2OX ; R , R = O- alpha -NANA (where NANA is N-acetylneuraminic acid), O- beta -NANA, OSO3H, or another monobasic acid; R = H, OH or 1-25C alkyl; or R +R = a six-membered substd. carbo- or heterocycle; Y = O- alpha -NANA, O- beta -NANA, OSO3H, or another monobasic acid; Z = a pyranose, a furanose or an open-chain polyalcohol; m, n, p, q = 1-20; X, X , X = H, NH2, COOH, OH, CH2OH, CH2NH, aryl, 1-25C alkyl or CH2O(CH2)qX; X = H, 1-25C alkyl or aryl; or X +X = O or S.