ACYL-SUBSTITUIERTE AMINOPYRANE MIT EINER MODULIERENDE WIRKUNG AUF KALIUMKANÄLE

Treatment of CNS conditions using acyl-substd. amino-pyrans of formula (I) and their salts is new. A = 6-10C aryl or pyridyl, opt. up to three times substd. by NO2, CN, Ph, halo, CF3, 1-6C alkylthio or 1-6C alkoxy; R1 = 1-8C alkyl; R2 = 1-6C alkyl; R3,R4 = H, 1-6C alkyl or 1-6C acyl; R5 = 1-8C alkyl...

Full description

Saved in:
Bibliographic Details
Main Authors JUNGE, BODO, DE VRY, JEAN-MARIE-VIKTOR, URBAHNS, KLAUS, HEINE, HANS-GEORG, WITTKA, REILINDE, MAULER, FRANK
Format Patent
LanguageGerman
Published 15.11.2000
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:Treatment of CNS conditions using acyl-substd. amino-pyrans of formula (I) and their salts is new. A = 6-10C aryl or pyridyl, opt. up to three times substd. by NO2, CN, Ph, halo, CF3, 1-6C alkylthio or 1-6C alkoxy; R1 = 1-8C alkyl; R2 = 1-6C alkyl; R3,R4 = H, 1-6C alkyl or 1-6C acyl; R5 = 1-8C alkyl or 1-8C alkoxy. Four cpds. falling within the above definitions are new i.e.: 5-acetyl-2-amino-6-methyl-4-(2,3-dichlorophenyl)-4H-pyran-3- carboxylic acid methyl ester (Ia), 5-acetyl-2-amino-6-methyl-4-(3,4-dichlorophenyl)-4H-pyran-3- carboxylic acid methyl ester, 5-acetyl-2-acetylamino-6-methyl-4-(2,3-dichlorophenyl)-4H-pyran- 3-carboxylic acid methyl ester, 5-acetyl-2-amino-6-methyl-4-(3-nitrophenyl)-4H-pyran-3-carboxylic acid methyl ester.
Bibliography:Application Number: AT19960112426T