SUBSTITUIERTE 4H-PYRANE MIT EINER MODULIERENDE WIRKUNG AUF KALIUMKANÄLE

Substd. 4H-pyran derivs. of formula (I) and their salts are new: A = 3-6C cycloalkyl; or 1-8C alkyl; or 6-10C aryl or pyridyl opt. substd. up to three times by NO2, OH, COOH, CN, 6-10C aryl, halo, 3-6C cycloalkyl, CF3 or 1-6C alkyl, 1-6C alkoxycarbonyl, 1-6C alkylthio or 1-6C alkoxy or a group -O-CO...

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Main Authors JUNGE, BODO, DE VRY, JEAN-MARIE-VIKTOR, URBAHNS, KLAUS, HEINE, HANS-GEORG, WITTKA, REILINDE, GLASER, THOMAS, MAULER, FRANK
Format Patent
LanguageGerman
Published 15.04.2000
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Substd. 4H-pyran derivs. of formula (I) and their salts are new: A = 3-6C cycloalkyl; or 1-8C alkyl; or 6-10C aryl or pyridyl opt. substd. up to three times by NO2, OH, COOH, CN, 6-10C aryl, halo, 3-6C cycloalkyl, CF3 or 1-6C alkyl, 1-6C alkoxycarbonyl, 1-6C alkylthio or 1-6C alkoxy or a group -O-CO-R5; R5 = 1-6C alkyl; R1, R2 = H, NH2, 1-8C alkyl, 1-8C alkoxy or 1-8C alkylamino; R3, R4 = 1-6C alkyl or 1-6C acyl. The following cpds. are excluded : 3,5-diacetyl-2,4,6-trimethyl-4H-pyran (Ia), 3,5-diethoxycarbonyl-2,6-dimethyl-4-phenyl-4H-pyran (Ib) and 3,5-diethoxycarbonyl-2,4,6-trimethyl-4H-pyran (Ic).
Bibliography:Application Number: AT19960112427T