6,7-MODIFIZIERTE 11-G(B)-ARYL-4-ESTRENE

PCT No. PCT/EP91/02493 Sec. 371 Date Oct. 27, 1993 Sec. 102(e) Date Oct. 27, 1993 PCT Filed Dec. 21, 1991 PCT Pub. No. WO92/11277 PCT Pub. Date Jul. 9, 1992Compounds of the general formula I (I) are described, in which x represents an oxygen atom or the hydroxyimino grouping >N DIFFERENCE OH, R1...

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Main Authors ELGER, WALTER, OTTOW, ECKHARD, FUHRMANN, ULRIKE, CLEVE, ARWED, SCHWEDE, WOLFGANG, CHWALISZ, KRZYSZTOF, SCHNEIDER, MARTIN
Format Patent
LanguageGerman
Published 15.08.1999
Edition6
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
STEROIDS
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Summary:PCT No. PCT/EP91/02493 Sec. 371 Date Oct. 27, 1993 Sec. 102(e) Date Oct. 27, 1993 PCT Filed Dec. 21, 1991 PCT Pub. No. WO92/11277 PCT Pub. Date Jul. 9, 1992Compounds of the general formula I (I) are described, in which x represents an oxygen atom or the hydroxyimino grouping >N DIFFERENCE OH, R1 represents a hydrogen atom or a methyl group, G represents a hydrogen atom, a halogen atom or a C1-C4-alkyl radical, when M and Q are hydrogen atoms or together are an additional bond, Q represents a C1-C4-alkyl radical when M and G are hydrogen atoms, or G and M together represent a methylene or ethylene group when Q is a hydrogen atom, and R2, R3 and R4 have the meanings given in the description. The novel compounds have pronounced antigestagenic and also antiglucocorticoid, antimineralocorticoid and antiandrogenic properties and are suitable for the preparation of medicaments.
Bibliography:Application Number: AT19920901410T