AMIDE MIT PHARMAKOLOGISCHER WIRKUNG, HERSTELLUNG UND DIESE VERBINDUNGEN ENTHALTENDE MITTEL UND VERWENDUNG

Compounds of the general formulawherein Ph is a phenyi group which is optionally substituted by one or more substituents selected from halo (ie fluoro, chloro, bromo or iodo), C1-4alkyl, amino, C1-4alkylamino, di-C1-4 alkylamino, nitro, sulphonyl, aminosulphonyl, trihalomethyl, carboxy, C1-4alkoxyca...

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Bibliographic Details
Main Authors HARDY, GEORGE WILLIAM, WILKINSON, SAMUEL
Format Patent
LanguageEnglish
German
Published 15.03.1986
Edition4
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds of the general formulawherein Ph is a phenyi group which is optionally substituted by one or more substituents selected from halo (ie fluoro, chloro, bromo or iodo), C1-4alkyl, amino, C1-4alkylamino, di-C1-4 alkylamino, nitro, sulphonyl, aminosulphonyl, trihalomethyl, carboxy, C1-4alkoxycarbonyl, amido, C1-4alkylamido, C1-4alkoxy, C2-4alkenyl, cyano, aminomethyl, or methylsulphonyl;Y is a group of formulawhere R1 is hydrogen or methyl;R2 is alkyl of 1 to 3 carbon atoms or is methylthiomethyl; and Z is -OR3 or -NR4R5 where R3, R4 and R5 are each hydrogen or alkyl of 1 to 4 carbon atoms and R3 can further be phenylalkyl having 1 to 3 carbon atoms in the alkylene moiety thereof, or phenyl; and basic salts thereof. These compounds have an advantageous enkephalinase inhibitory activity which renders the compounds useful in medical therapy, eg. to prolong and/or potentiate in a mammal, the effects of endogenous or exogenous enkephalins. The latter includes synthetic enkehalin analogues.
Bibliography:Application Number: AT19820108860T