CHINUCLIDINE DERIVATE ALS SQUALEN SYNTHASE INHIBITORE
Compounds of formula (I) and their pharmaceutically acceptable salts in which R is hydrogen or hydroxy; R is hydrogen; or R and R are joined together so that CR -CR is a double bond; X is selected from -CH2CH2-, -CH=CH-, -C=C, -CH2O-, -OCH2-, -CH2NH-, -NHCH2-, -CH2CO-, -COCH2-, -NHCO-, -CONH-, -CH2S...
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Main Authors | , , |
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Format | Patent |
Language | German |
Published |
15.09.1998
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Edition | 6 |
Subjects | |
Online Access | Get full text |
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Summary: | Compounds of formula (I) and their pharmaceutically acceptable salts in which R is hydrogen or hydroxy; R is hydrogen; or R and R are joined together so that CR -CR is a double bond; X is selected from -CH2CH2-, -CH=CH-, -C=C, -CH2O-, -OCH2-, -CH2NH-, -NHCH2-, -CH2CO-, -COCH2-, -NHCO-, -CONH-, -CH2S-, -SCH2-, wherein the sulphur atom in the latter two groups may optionally bear one or two oxygen atoms; Ar is a phenylene moiety; Ar is phenyl; and wherein one or both of Ar and Ar may be optionally unsubstituted or independently substituted by one or more substituents selected from halogeno, hydroxy, amino, nitro, cyano, carboxy, carbamoyl, alkyl, alkenyl, alkynyl, alkoxy, alkylamino, di-alkylamino, N-alkylcarbamoyl, N,N-di-alkylcarbamoyl, alkoxycarbonyl, alkylthio, alkylsulphinyl, alkylsulphonyl, halogenoalkyl, alkanoyl, methylenedioxy and alkanoylamino; are inhibitors of squalene synthase and hence useful in treating medical conditions in which a lowering of cholesterol is beneficial, such as hypercholesterolemia and atherosclerosis. Processes for preparing these derivatives, pharmaceutical compositions containing them are also described together with their use in medicine. |
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Bibliography: | Application Number: AT19930908010T |