VERFAHREN ZUR HERSTELLUNG VON 2-(1-PENTYL-3- GUANIDINO)-4-(2-METHYL-4-IMIDAZOLYL)THIAZOL UND DESSEN KRISTALLINISCHES DIHYDROCHLORID-TRIHYDRAT

A process for the preparation of a compound of the formula:- R is benzyl or C1-C5 alkyl, and R is C1-C5 alkyl, which comprises heating a compound of the formula:- either in acid addition salt form, or in the presence of an acid catalyst, with at least one molar equivalent of an amine of the formula:...

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Bibliographic Details
Main Authors SNYDER, WILLIAM MICHAEL, CUE, BERKELEY WENDELL, JR, ALLEN, DOUGLAS JOHN MELDRUM, WALINSKY, STANLEY WALTER, HILL, PAUL DAVID
Format Patent
LanguageGerman
Published 15.06.1994
Edition5
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:A process for the preparation of a compound of the formula:- R is benzyl or C1-C5 alkyl, and R is C1-C5 alkyl, which comprises heating a compound of the formula:- either in acid addition salt form, or in the presence of an acid catalyst, with at least one molar equivalent of an amine of the formula:- R-NH2 either neat or in a reaction-inert solvent. Also claimed is cryatalline 2-(1-pentyl-3-quanidino)-4-(2-methyl-4-imidazolyl)thiazole dihydrochloride trihydrate, preparable by the above process.
Bibliography:Application Number: AT19870309159T