VERFAHREN ZUR HERSTELLUNG VON NEUEN 3,4-DIHYDOR-5H-2,3-BENZODIAZEPINDERIVATEN SOWIE VON DEREN SAEUREADDITIONSSALZEN

The invention relates to new 3,4-dihydro-5H-2,3-benzodiazepine derivatives of general formula (I) and pharmaceutically acceptable acid addition salts thereof, (I) wherein R represents a phenyl group optionally carrying one or two substituents selected from the group consisting of halogen, hydroxy, C...

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Main Authors ANDRASI FERENC DR, BALOGH TIBOR DR, LANG TIBOR DR, KOROESI JENO DR, HAMORI TAMAS, GOLDSCHMIDT KATALIN DR, ILA LAJOS, MORAVCSIK IMRE, SZEKELY JOZSEF DR, SINEGER ELEONORA DR
Format Patent
LanguageGerman
Published 15.10.1986
Edition4
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to new 3,4-dihydro-5H-2,3-benzodiazepine derivatives of general formula (I) and pharmaceutically acceptable acid addition salts thereof, (I) wherein R represents a phenyl group optionally carrying one or two substituents selected from the group consisting of halogen, hydroxy, C1-4 alkoxy and benzyloxy; a furyl or a thienyl group, R1 stands for a hydrogen atom or a C1-4 alkyl group, R2 and R3 each represent hydrogen atom, C1-4 alkoxy, C4-7 cycloalkoxy or benzyloxy group. The new compounds of the general formula (I) can be prepared by reducing a 5H-2,3-benzodiazepine derivative of the general formula (II) (II) wherein R, R1, R2 and R3 have the above-defined meanings, with an inorganic or organic hydride and/or complex metal hydride. The new compounds of the general formula (I) possess significant central nervous effects and can advantageously be used in the therapy.
Bibliography:Application Number: AT96982