VERFAHREN ZUR HERSTELLUNG VON NEUEN 3-(2'-ACYLPHENOXY)-2-HYDROXY-1-ALKYLAMINOPROPANEN UND DEREN SAUREADDITIONSSALZEN

The present invention relates to phenoxypropane having the formula in which R1 and R2 are like or unlike and each is an alkyl group having 1-4 carbon atoms, R3 is hydrogen or an alkyl group having 1-4 carbon atoms, R4 is a halogen atom, preferably fluorine, chlorine or bromine, including their optic...

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Bibliographic Details
Main Author DEMARNE HENRI
Format Patent
LanguageGerman
Published 15.09.1977
Edition2
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to phenoxypropane having the formula in which R1 and R2 are like or unlike and each is an alkyl group having 1-4 carbon atoms, R3 is hydrogen or an alkyl group having 1-4 carbon atoms, R4 is a halogen atom, preferably fluorine, chlorine or bromine, including their optical isomers and also their addition salts with acids. These compounds are of therapeutic value in the treatment of cardiovascular conditions. The invention also relates to methods of synthesis of these products including a synthesis which involves the production, as a intermediate of an 8-aza-4,9-dioxa-2,3-benzo-bicyclo-[4,2,1]-octane having the formula in which R1 and R4 are as above defined.
Bibliography:Application Number: AT497275