VERFAHREN ZUR HERSTELLUNG EINES ANTIBIOTIKUMS

The invention relates to a microbial process for the production of immunosuppressive cyclosporine antibiotic complex or of its components, cyclosporine A, cyclosporine B and cyclosporine C, by the aerobic fermentation of a filamentous fungus strain biosynthesizing the above antibiotic(s) in a nutrie...

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Main Authors NAGY KAROLY, SANTHA GYOERGY, TOTH SARUDY EVA DR, DELI ETELKA DR, AMBRUS GABOR . DR, PALOTAS BELA, MOLNAR ANIKO DR, HUELBER AGOTA, MORAVCSIK IMRE, JEKKEL ANTONIA DR, SZABO ISTVAN MIHALY DR, ANDOR ATTILA, TOMORI EVA DR, POLYA KALMAN DR, KISS LAJOS, ALBRECHT KAROLY, ERDEI JANOS DR, BUZASI KAROLY, SZASZHEGYESI VILMA, MAKADI BELA, KOENCZOEL KALMAN . DR, SZELL VALERIA . DR
Format Patent
LanguageGerman
Published 15.01.1991
Edition5
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROCESSES USING MICROORGANISMS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:The invention relates to a microbial process for the production of immunosuppressive cyclosporine antibiotic complex or of its components, cyclosporine A, cyclosporine B and cyclosporine C, by the aerobic fermentation of a filamentous fungus strain biosynthesizing the above antibiotic(s) in a nutrient medium containing utilizable carbon and nitrogen sources as well as mineral salts, and by isolating the products formed, which comprises culturing a strain of the novel Tolypocladium varium fungus species producing the cyclosporine antibiotic complex, preferably tolypocladium varium sp. nov. CY/93, deposited at the National Collection of Agricultural and Industrial Microorganisms, Budapest, Hungary under the number NCAIM(P)F 001005, on a nutrient medium containing carbon sources, organic and inorganic nitrogen sources as well as mineral salts, under aerobic conditions, at 25 DEG to 30 DEG C., and, if desired, isolating and purifying the cyclosporine antibiotic complex or its components produced.
Bibliography:Application Number: AT289189