MODIFIZIERTE OLIGONUKLEOTIDE, VERFAHREN ZU IHRER HERSTELLUNG UND VERWENDUNG ALS WIRKSTOFFE ZUR HERSTELLUNG VON ARZNEIMITTELN

The invention pertains to 10 to 50-mer oligonucleotides which, with the attachment of appropriate radicals that carry basic groups, are capable of forming amphoteric ions via intramolecular ammonium salts. Oligonucleotides modified in this way do not lose their ability to pair with their complementa...

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Bibliographic Details
Main Authors NOE CHRISTIAN DR, BRUNAR HELMUT
Format Patent
LanguageGerman
Published 25.05.2001
Edition7
Subjects
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Summary:The invention pertains to 10 to 50-mer oligonucleotides which, with the attachment of appropriate radicals that carry basic groups, are capable of forming amphoteric ions via intramolecular ammonium salts. Oligonucleotides modified in this way do not lose their ability to pair with their complementary strand. Such oligonucleotides can be expected to show a greater nuclease resistance and better membrane penetrability than natural oligonucleotides. This yields important benefits for antisense therapy.
Bibliography:Application Number: AT250593