Process for the preparation of novel water-soluble carbohydrate derivatives

A process for the preparation of novel water-soluble carbohydrate derivatives with radicals, linked via ester functions, of bioactive substances of the general formula I in which X1 is H, X, CH3, C2H5, CH2CH2OH, CH2CH(OH)CH3, CH2CH(OH)CH2OH or a radical -A or alpha- or beta-4-bonded glucose residue...

Full description

Saved in:
Bibliographic Details
Main Authors GREBER GERHARD. DR, GRUBER HEINRICH. DR
Format Patent
LanguageEnglish
German
Published 10.05.1989
Edition4
Subjects
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
Online AccessGet full text

Cover

More Information
Summary:A process for the preparation of novel water-soluble carbohydrate derivatives with radicals, linked via ester functions, of bioactive substances of the general formula I in which X1 is H, X, CH3, C2H5, CH2CH2OH, CH2CH(OH)CH3, CH2CH(OH)CH2OH or a radical -A or alpha- or beta-4-bonded glucose residue and, in the case of monosaccharides, not more than one radical X and, in the case of disaccharides, not more than three radicals X are the bioactive substance radicals 2-(3- benzoylphenyl)propionyl, 2-propylvaleryl, 2-(6-methoxy-2- naphthyl)propionyl, 1-(4-chlorobenzoyl)-5-methoxy-2- methylindole-3-acetyl and 2-(2,4- dichlorophenoxy)propionyl, and the other radicals X are hydrogen, comprises reacting the bioactive substance compounds corresponding to the above-defined radical X, in the form of the free carboxylic acid or its acid derivatives, in particular acid chlorides, with a carbohydrate of the general formula II in which X'1 is H, CH3, C2H5, CH2CH2OH, CH2CH(OH)CH3, CH2CH(OH)CH2OH or a radical -A' or alpha- or beta-4-bonded glucose residue.
Bibliography:Application Number: AT19860001508