VERFAHREN ZUR HERSTELLUNG VON NEUEN BENZO-AS-TRIAZIN-DERIVATEN

• Main Authors: KOSOCZKY IBOLYA DR, MESSMER ANDRAS DR, HAJOS GYOERGY DR, BENKO PAL. DR, PETOECZ LUJZA DR, GOEROEG PETER DR
• Format: Patent
• Language: German
• Published: 12.05.1986
• Edition: 4
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to new benzo-as-triazine derivatives of the formulae (I) and (Ia) and pharmaceutically acceptable acid addition salts thereof, (I) (Ia) wherein R1 and R2 each represent hydrogen, a C1-20 alkylcarbonyl group, a phenylcarbonyl or phenyl-(C1-4 alkyl)-carbonyl group having optionally one or more halogen, hydroxy or C1-3 alkoxy substituents which may be the same or different, furthermore a pyridylcarbonyl, a pyrazinylcarbonyl, a furylcarbonyl, a chloroacetyl or a C1-4 alkoxycarbonyl group, or R1 and R2 may form, together with the adjacent nitrogen atoms, a pyrazole ring having optionally a C1-6 alkyl substituent in position 4, with the proviso that one of R1 and R2 is always different from hydrogen, R3 stands for hydrogen, mercapto group, a C1-4 alkylmercapto group, amino group, a C1-4 alkylamino group, a piperazino group having optionally an N-alkyl or 2-pyridyl substituent, a morpholino group or a piperidino group, and R4 stands for hydrogen, halogen, C1-4 alkyl or C1-4 alkoxy group. The compounds of the formulae (I) and (Ia) are prepared by acylating the respective 2,4,5-unsubstituted 4,5-dihydro-benzo-as-triazine derivatives. The new compounds of the formulae (I) and (Ia) possess analgesic, antiphlogistic and narcosis-potentiating effects.