VERFAHREN ZUR HERSTELLUNG VON NEUEN PEPTIDYL-ARGININ-ALDEHYD-DERIVATEN SOWIE VON SALZEN DIESER VERBINDUNGEN

Novel peptidyl-arginine aldehyde derivatives and their salts of formula I, wherein X represents a hydrogen atom, benzoyl or tert-butyloxycarbonyl group, and Y is a D-phenylalanine, beta -phenyl-D-lactic acid or D-allo-isoleucine moiety, are prepared from peptidyl-arginine aldehydes protected by an u...

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Bibliographic Details
Main Authors BAJUSZ SANDOR DR, BARABAS EVA DR, SZELL ERZSEBET, BAGDY DANIEL DR
Format Patent
LanguageGerman
Published 25.08.1983
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Novel peptidyl-arginine aldehyde derivatives and their salts of formula I, wherein X represents a hydrogen atom, benzoyl or tert-butyloxycarbonyl group, and Y is a D-phenylalanine, beta -phenyl-D-lactic acid or D-allo-isoleucine moiety, are prepared from peptidyl-arginine aldehydes protected by an urethane type protecting group on their N- or O-terminal and/or a guanidino group, by removing the protecting group in a mixture of lower alkanols and water by means of hydrogenolysis, and eventually converting the product formed into a salt. The compounds of formula I possess valuable antithrombin activity.
Bibliography:Application Number: AT1280