Verfahren zur Herstellung von neuen 17-Aza-steroiden und deren Salzen

A process for the preparation of new 21-substituted-17-aza steroids of the general formula i ** (see formula) ** Wherein a and b each represent a hydrogen atom; c is a hydroxy group or a protected hydroxy group, preferably an ester or ether group; d, e and f each represent a hydrogen atom; g is a me...

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Bibliographic Details
Main Authors MARIA BOR, ZOLTAN TUBA
Format Patent
LanguageGerman
Published 25.05.1973
Edition1
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
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Summary:A process for the preparation of new 21-substituted-17-aza steroids of the general formula i ** (see formula) ** Wherein a and b each represent a hydrogen atom; c is a hydroxy group or a protected hydroxy group, preferably an ester or ether group; d, e and f each represent a hydrogen atom; g is a methyl group, if the compound is androstanic type; a and b, d and e and f and g, each represent, together, a double bond; c and d represent, together, an oxo group or a protected oxo group, preferably a ketal group; x represents a chlorine or bromine atom, as well as its salts, In which acylate, conforms to the schotten-baumann method, one of the compounds of the general formula ii ** (see formula) ** Wherein a, b, c, d, e, f, g, ab, de, fg and cd have the same meanings as indicated above, with a compound of general formula iii ** (see formula) ** Wherein y and x represent a chlorine and/or bromine atom, and the 17-aza-20-keto-21-haloesteroid thus obtained, of general formula i, is optionally subjected, directly or after hydrolyzing the ketal group located in position 3, to an institution reaction. (Machine-translation by Google Translate, not legally binding)
Bibliography:Application Number: AT502371