CÉLULA VECTOR ADYUVANTE ARTIFICIAL CON CONTENIDO DE NY-ESO-1 PARA USAR EN EL TRATAMIENTO DEL CÁNCER

• Main Authors: AKIBA, AYAKA, OKUDAIRA, TATSUYA, OHSUMI, KEISUKE, FUJII, SHINICHIRO, MASUHARA, YASUHIDE
• Format: Patent
• Language: Spanish
• Published: 09.03.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Un objetivo de la presente es dar a conocer una célula aAVC-NY-ESO-1 clínicamente aplicable que expresa NY-ESO-1 de manera estable para usar las células aAVC-NY-ESO-1 en el tratamiento de pacientes con cáncer que expresa NY-ESO-1. La presente brinda, por ejemplo, una célula de origen humano que comprende un polinucleótido que codifica CD1d y un polinucleótido que codifica NY-ESO-1 o un fragmento de ésta, donde el polinucleótido que codifica NY-ESO-1 o un fragmento de ésta está operativamente ligado a un promotor inducible. An object of the present invention is to provide clinically applicable aAVC-NY-ESO-1 cells stably expressing NY-ESO-1 in order to use aAVC-NY-ESO-1 cells in treating patients having a NY-ESO-1-expressing cancer. The present invention provides, for example, a human-derived cell comprising a polynucleotide encoding CD1d and a polynucleotide encoding NY-ESO-1 or a fragment thereof, wherein the polynucleotide encoding NY-ESO-1 or a fragment thereof is operably linked to an inducible promoter.