COMPUESTOS, PROCEDIMIENTO DE OBTENCIÓN DE LOS COMPUESTOS, COMPOSICIÓN FARMACÉUTICA, USO DE LOS COMPUESTOS Y MÉTODO DE TRATAMIENTO DE DESÓRDENES PSIQUIÁTRICOS Y/O TRASTORNOS DEL SUEÑO

• Main Authors: FREIRE TORRES RUSSO, VALTER, ZANETI DE AZEVEDO, HATYLAS FELYPE, RUCH WERNECK GUIMARES, CRISTIANO, WATANABE DA COSTA, RENATA, MASCARELLO, ALESSANDRA, MANNOCHIO DE SOUZA RUSSO, ELISA
• Format: Patent
• Language: Spanish
• Published: 12.12.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Reivindicación 1: Compuesto, caracterizado por presentar la fórmula general (1), donde X corresponde a un átomo de oxígeno o de azufre; A corresponde a un grupo alquilo lineal C₂₋₄, el cual puede tener uno o más de sus hidrógenos sustituido(s) por un grupo alquilo seleccionado de metilo, etilo, propilo o isopropilo; R¹ corresponde a un grupo alquilo C₁₋₆, o alquenilo C₂₋₆, o alquinilo C₂₋₆, o haloalquilo C₁₋₆, o cicloalquilo C₃₋₆, o alquilo C₁₋₂-cicloalquilo C₃₋₆; R² corresponde a un hidrógeno o un grupo alquilo C₁₋₃; R³ corresponde a un átomo de hidrógeno o de halógeno; R⁴ corresponde a un grupo alquilo C₁₋₆; n es 0 ó 1. The present invention relates to novel and inventive pharmacologically active benzimidazole derivative compounds, which surprisingly have high affinity for melatonin MT1 and MT2 receptors and low affinity for CYP450 complex enzymes, specially CYP1A2. The present invention also relates to novel and inventive routes of synthesis of these compounds, pharmaceutical compositions comprising the compounds and the use of these compounds in the treatment of individuals affected by psychiatric disorders and/or sleep disorders related to these receptors (specially depression, anxiety, circadian cycle disorders), in addition to process for producing the composition.