MÉTODOS DE TRATAMIENTO DE NEURALGIA POSTHERPÉTICA CON UNA FORMULACIÓN TÓPICA DE UN COMPUESTO DE ESPIRO-OXINDOL

• Main Authors: MICHAEL J. LAMSON, NICOLA ANNE PRICE, RICHARD MALAMUT, OFER SPIEGELSTEIN, YIGAL PAUL GOLDBERG, MICHAEL FETELL
• Format: Patent
• Language: Spanish
• Published: 24.05.2017
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Reivindicación 1: Un método para tratar la neuralgia postherpética en un mamífero, caracterizado porque comprende administrar en un área de piel afectada del mamífero una composición farmacéutica tópica que comprende uno o más excipientes y una cantidad terapéuticamente eficaz de un compuesto de espiro-oxindol que tiene la fórmula (1). Methods of treating postherpetic neuralgia in a mammal with a pharmaceutical composition comprising a spiro-oxindole compound of the formula: are disclosed. The methods provide excellent penetration of the spiro-oxindole compound into the affected skin area to effectively reduce the severity of the postherpetic neuralgia and/or to alleviate the postherpetic neuralgia with minimal or negligible systemic exposure of the spiro-oxindole compound.