DERIVADOS HETEROCICLICOS, SU PROCEDIMIENTO DE PREPARACION Y LAS COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN

• Main Authors: JENNEQUIN, THOMAS, BRIOCHE, JULIEN, DACQUET, CATHERINE, CAIGNARD, DANIEL-HENRI, KTORZA, ALAIN, LIUTKUS, MELANIE, GREE, RENE, CAIJO, FREDERIC
• Format: Patent
• Language: Spanish
• Published: 04.03.2009
• Edition: 7

Reivindicacion 1: Compuestos de formula (1) en la que R1 representa alquilo C1-6 lineal o ramificado sustituido con uno o varios grupos COOR3 o NR4R5, en los que R3 representa un átomo de H o alquilo C1-6 lineal o ramificado; R4 representa un grupo COOR'3 o alquilo C1-6 lineal o ramificado sustituido con un grupo COOR'3 en el que R'3 representa un átomo de H o alquilo C1-6 lineal o ramificado; R5 representa alquilo C1-6 lineal o ramificado sustituido con un grupo fenilo no sustituido o sustituido con 1 a 3 grupos alquilo C1-6 lineal o ramificado, alcoxi C1-6 lineal o ramificado, polihaloalquilo C1-6 lineal o ramificado o átomos de halogeno; R2 representa un grupo fenilo no sustituido o sustituido con uno o varios grupos alquilo C1- 6 lineal o ramificado, alcoxi C1-6 lineal o ramificado, polihaloalquilo C1-6 lineal o ramificado o átomos de halogeno, n vale 0, 1, 2, 3, 4, 5, 6, 7 u 8, sus enantiomeros y diastereoisomeros así como sus sales de adicion a un ácido o a una base aceptables farmacéuticamente. Quinoline derivatives of formula (I), their enantiomers, diastereoisomers, and their acid or base addition salts, are new. Quinoline derivatives of formula (I), their enantiomers, diastereoisomers, and their acid or base addition salts, are new. R 11-6C alkyl (substituted by COOR 3 or -NR 4R 5), preferably -(CH 2) 3-COOR 3, -(CH 2) 2-C(Me) 2-COOR 3 or -CH 2-NR 4R 5; R 4-COOR 3 a or 1-6C alkyl (substituted by COOR 3 a); R 3, R 3 aH or 1-6Calkyl; R 51-6C alkyl (substituted by phenyl (optionally substituted by 1-3 substituents of 1-6C alkoxy, 1-6C (polyhalo)alkyl or halo)); R 2phenyl (optionally substituted by 1-6C alkyl, 1-6C alkoxy or 1-6C polyhaloalkyl or halo); and n : 0-8. Independent claims are included for: (1) the preparation of (I); and (2) a combination containing (I) and an antioxidant agent. [Image] ACTIVITY : Antidiabetic; Antilipemic; Metabolic; Cardiovascular-Gen.; Cardiant; Vasotropic; Nephrotropic; Ophthalmological; Antipsoriatic; Gynecological; Nootropic; Osteopathic; Gastrointestinal-Gen; Antiarteriosclerotic; Anorectic; Eating-Disorders-Gen.; Cytostatic; Muscular-gen; Anabolic. MECHANISM OF ACTION : Aldose reductase inhibitor.