Substituted indolepyridinium as anti-infective compounds

The present invention concerns the compounds of formula (I) their N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites, wherein n is 1, 2 or 3; R1is H, CN, halo, aminoC(-O), C(-O)OH, C1-4alkyloxyC(-O), C1-4alkylC(-O), mono- or di(C1-4alkyl)aminoC(-O), arylaminoC(...

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Bibliographic Details
Main Authors VAN DE VREKEN WIM, DE VROEY VERONIQUE CORINE PAUL, KESTELEYN BART RUDOLF ROMANIE ET AL
Format Patent
LanguageEnglish
Published 30.06.2005
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention concerns the compounds of formula (I) their N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites, wherein n is 1, 2 or 3; R1is H, CN, halo, aminoC(-O), C(-O)OH, C1-4alkyloxyC(-O), C1-4alkylC(-O), mono- or di(C1-4alkyl)aminoC(-O), arylaminoC(-O), N-(aryl)-N-(C1-4alkyl)aminoC(-O), methanimidamidyl, N-hydroxy-methanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl, Het1 or Het2; R2 is H, C1-10alkyl, C2-10alkenyl, C3-7cycloalkyl, wherein said C1-10alkyl, C2-10alkenyl and C3-7cycloalkyl may be optionally substituted; R3 is nitro, cyano, amino, halo, hydroxy, C1-4alkyloxy, hydroxyC(-O), aminoC(-O), C1-4alkyloxyC(-O), mono- or di(C1-4alkyl)aminoC(-O), C1-4alkylC(-O), methanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl, N-hydroxy-methanimidamidyl or Het1; for use as a medicine. The invention further relates to a novel subgroup of the compounds of formula (I), and to compositions comprising compounds of formula (I).
Bibliography:Application Number: AP20050003334