Diaminothiazoles and their use for inhibiting protein kinases

• Main Authors: BENDER Stephen L, BORCHARDT Allen J, TEMPCZYK-RUSSELL Anna Maria, YANG Yi Michelle, ALEGRIA Larry Andrew, KANIA Robert Steven, BENEDICT Suzanne Pritchett, NAMBU Mitchel David, PENG Zhengwei, SARSHAR Sepehr, BHUMRALKAR Dilip, CHU Shao Song
• Format: Patent
• Language: English
• Published: 31.12.2001
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Diaminothiazole compounds of formula (i)that module and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction in order to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.