Triamide-substituted heterobicyclic compounds

The invention relates to triamide MTP/ApoB inhibitors of formula 1 wherein R1 - R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for preparing the compounds. The compounds of the invention are useful for the treatment of obesity and lipid...

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Bibliographic Details
Main Authors HUATAN Hiep, BERTINATO Peter, BLIZE Alan Elwood, MASON Clive Philip, LI Jin, BRONK Brian Scott, CHENG Hengmiao
Format Patent
LanguageEnglish
Published 07.08.2006
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to triamide MTP/ApoB inhibitors of formula 1 wherein R1 - R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for preparing the compounds. The compounds of the invention are useful for the treatment of obesity and lipid disorders.
Bibliography:Application Number: AP20020002567