The binding proximity of methyl b-lilacinobioside isolated from Caralluma retrospiciens with topoisomerase II attributes apoptosis in breast cancer cell line
The alterations in somatic genomes that controls the mechanism of cell division as a main cause of cancer, and then the drug that specifically toxic to the cancer cells further complicates the process of the development of the widely effective potential anticancer drug. The side effects of the drug...
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Published in | Saudi journal of biological sciences Vol. 25; no. 8; pp. 1826 - 1833 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Riyadh, Saudi Arabia
Saudi Biological Society
2018
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Subjects | |
Online Access | Get full text |
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Summary: | The alterations in somatic genomes that controls the mechanism of cell division as a main cause of cancer,
and then the drug that specifically toxic to the cancer cells further complicates the process of the
development of the widely effective potential anticancer drug. The side effects of the drug as well as
the radiotherapy used for the treatment of cancer is severe; therefore, the search of the natural products
from the sources of wild plants having anticancer potential is become immense importance today. The
ethno-medicinal survey undertaken in Al-Fayfa and Wadi-E-Damad region of southern Saudi Arabia
revealed that the Caralluma retrospiciens (Ehrenb.) N.E.Br. (family Apocynaceae) is being used for the
treatment of cancer by the native inhabitants. The biological evaluation of anticancer potential of
bioassay-guided fractionations of methanolic extract of whole plant of C. retrospiciens against human
breast adenocarcinoma cell line (MCF-7) followed by characterization using spectroscopic methods confirmed
the presence of methyl b-lilacinobioside, a novel active constituent reported for the first time from
C. retrospiciens, is capable of inhibition of cell proliferation and induction of apoptosis in MCF-7 cells by
regulating ROS mediated autophagy, and thus validated the folkloric claim. Based on a small-scale
computational target screening, Topoisomerase II was identified as the potential binding target of methyl
b-lilacinobioside. |
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ISSN: | 1319-562X |