Preparation and biological evaluation of 99mTc-TMPP as a novel agent for tumor diagnosis

TMPP (5, 10, 15, 20 tetrakis {4-methoxyphenyl} 21H, 23H porphyrin) was labeled with technetium-99m via direct labeling technique using stannous chloride as a reducing agent. The optimum conditions that gave high labeling yield (95.2%) of 99mTc-TMPP complex were achieved by using 3mg TMPP, 100g SnCl...

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Bibliographic Details
Published inArab Journal of Nuclear Sciences and Applications. Vol. 49; no. 1; pp. 131 - 137
Main Authors Lashine, E. M., Abd al-Aziz, L. M., Fayid, M., Mutalib, M. A., al-Kulali, M. T.
Format Journal Article
LanguageEnglish
Published Cairo, Egypt The Egyptian Society of Nuclear Science and Applications 2016
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Summary:TMPP (5, 10, 15, 20 tetrakis {4-methoxyphenyl} 21H, 23H porphyrin) was labeled with technetium-99m via direct labeling technique using stannous chloride as a reducing agent. The optimum conditions that gave high labeling yield (95.2%) of 99mTc-TMPP complex were achieved by using 3mg TMPP, 100g SnCl2.2H2O, at pH 3 and 30min reaction time. Accumulation of 99mTc-TMPP complex was studied in tumor bearing mice. After intravenous injection of 99mTc-TMPP complex, tumor radioactivity uptake was high compared to normal muscle uptake and it was 7.76 folds after 30 min. Tumor to blood ratio was 2.36 after 30 min
ISSN:1110-0451
2090-4258