Effect of a Novel Potential Atypical Antipsychotic Drug, Y-931, in Producing Dystonia in Cebus Monkeys

The effect of Y-931 (8-fluoro-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine maleate), a novel potential atypical antipsychotic candidate, in producing dystonia in Cebus monkeys was investigated. Y-931 induced relatively weak dystonia in several observation periods at doses...

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Bibliographic Details
Published inJournal of pharmacological sciences Vol. 93; no. 3; pp. 364 - 366
Main Authors Shiigi, Yasuyuki, Maeda, Jun-ichi, Yasumatsu, Hiroshi, Tanaka, Hiroshi, Casey, Daniel E.
Format Journal Article
LanguageEnglish
Published Elsevier B.V 2003
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Summary:The effect of Y-931 (8-fluoro-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine maleate), a novel potential atypical antipsychotic candidate, in producing dystonia in Cebus monkeys was investigated. Y-931 induced relatively weak dystonia in several observation periods at doses greater than 0.1 mg/kg, i.m. Although Y-931 significantly increased total dystonia scores (the sum of 15 to 360 min after injection) at doses greater than 0.5 mg/kg, i.m., the scores did not exceed 20, up to a dose of 1.0 mg/kg, i.m. and lacked a dose-response relationship. The present result suggests that Y-931 is predicted to have a low risk of extrapyramidal side effects.
ISSN:1347-8613
1347-8648
DOI:10.1254/S1347-8613(19)32587-3