Emergence of Klebsiella pneumoniaecarrying the novel extended-spectrum β-lactamase gene variantsblaSHV-40, blaTEM-116 and the class 1 integronassociatedblaGES-7 in Brazil

A clinical Klebsiella pneumoniae isolate carrying the extended-spectrum β-lactamase gene variants blaSHV-40, blaTEM-116 and blaGES-7 was recovered. Cefoxitin and ceftazidime activity was most affected by the presence of these genes and an additional resistance to trimethoprim-sulphamethoxazole was o...

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Published inClinical microbiology and infection Vol. 16; no. 6; pp. 630 - 632
Main Authors Dropa, M., Balsalobre, L.C., Lincopan, N., Mamizuka, E.M., Cassettari, V.C., Matté, G.R., Matté, M.H.
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.06.2010
Subjects
blaGES
blaSHV
blaTEM
class 1 integron
extended-spectrum
Klebsiella pneumoniae
Latin America
β-lactamase
blaSHV
blaGES
extended-spectrum
β-lactamase
class 1 integron
Klebsiella pneumoniae
blaTEM
Latin America
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Summary:A clinical Klebsiella pneumoniae isolate carrying the extended-spectrum β-lactamase gene variants blaSHV-40, blaTEM-116 and blaGES-7 was recovered. Cefoxitin and ceftazidime activity was most affected by the presence of these genes and an additional resistance to trimethoprim-sulphamethoxazole was observed. The blaGES-7 gene was found to be inserted into a class 1 integron. These results show the emergence of novel blaTEM and blaSHV genes in Brazil. Moreover, the presence of class 1 integrons suggests a great potential for dissemination of blaGES genes into diverse nosocomial pathogens. Indeed, the blaGES-7 gene was originally discovered in Enterobacter cloacae in Greece and, to our knowledge, has not been reported elsewhere.
ISSN:1198-743X
1469-0691
DOI:10.1111/j.1469-0691.2009.02944.x