Bioassay of Vitamin K by Intracardial Injection in Deficient Adult Male Rats1

The biological activity of vitamin K was determined by intracardial injection in partially depleted adult male rats. Prothrombin levels rose rapidly after the injection of phylloquinone. Response to menadione was delayed for several hours. The relative molar activity of several forms of vitamin K wa...

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Bibliographic Details
Published inThe Journal of nutrition Vol. 94; no. 1; pp. 57 - 59
Main Authors Matschiner, John T., Taggart, W.V.
Format Journal Article
LanguageEnglish
Published Elsevier Inc 01.01.1968
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Summary:The biological activity of vitamin K was determined by intracardial injection in partially depleted adult male rats. Prothrombin levels rose rapidly after the injection of phylloquinone. Response to menadione was delayed for several hours. The relative molar activity of several forms of vitamin K was determined. Menaquinones with side chains containing more than six isoprene units were up to 25 times as active as phylloquinone.
ISSN:0022-3166
DOI:10.1093/jn/94.1.57