Highly diastereoselective synthesis of 2-monosubstituted 1 R,5 S(1 S,5 R)-glycoluriles on the basis of S- and R- N-carbamoyl-α-amino acids

The reactions of 4,5-dihydroxyimidazolidin-2-one with chiral S- and R-N-carbamoyl-α-amino acids occur diastereoselectively with the formation of corresponding 1 R, 5S(1S,5R)-glycoluriles as predominant diastereomers; the absolute configuration is determined for three stereoisomers by X-ray diffracti...

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Published inMendeleev communications Vol. 13; no. 6; pp. 269 - 271
Main Authors Kravchenko, Angelina N., Chegaev, Konstantin Yu, Chikunov, Il’ya E., Belyakov, Pavel A., Maksareva, Elena Yu, Lyssenko, Konstantin A., Lebedev, Oleg V., Makhova, Nina N.
Format Journal Article
LanguageEnglish
Published Elsevier B.V 2003
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Summary:The reactions of 4,5-dihydroxyimidazolidin-2-one with chiral S- and R-N-carbamoyl-α-amino acids occur diastereoselectively with the formation of corresponding 1 R, 5S(1S,5R)-glycoluriles as predominant diastereomers; the absolute configuration is determined for three stereoisomers by X-ray diffraction analysis.
ISSN:0959-9436
DOI:10.1070/MC2003v013n06ABEH001802