Convenient synthesis of 4 H-1,2,4-triazole-3-thiols using di-2-pyridylthionocarbonate

We report here the convenient synthesis of 4 H-1,2,4-triazole-3-thiols using di-2-pyridyl-thionocarbonate as the thiocarbonyl transfer reagent. This method is suitable for microplate parallel synthesis and produces samples in screening-ready condition. It uses two large sets of building-blocks: amin...

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Bibliographic Details
Published inTetrahedron letters Vol. 48; no. 46; pp. 8157 - 8162
Main Authors Deprez-Poulain, Rebecca F., Charton, Julie, Leroux, Virginie, Deprez, Benoit P.
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 2007
Subjects
cis-Amides
DPT
Parallel synthesis
Solubility
Triazol-3-thiols
Triazol-3-thiols
cis-Amides
Parallel synthesis
Solubility
DPT
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Summary:We report here the convenient synthesis of 4 H-1,2,4-triazole-3-thiols using di-2-pyridyl-thionocarbonate as the thiocarbonyl transfer reagent. This method is suitable for microplate parallel synthesis and produces samples in screening-ready condition. It uses two large sets of building-blocks: amines and hydrazides.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2007.09.094