New C 21 Δ 20 pregnanes, inhibitors of mitochondrial respiratory chain, from Indopacific octocoral Carijoa sp

The isolation and characterization of two new pregnanes (i.e., compound 1 ), together with previously found metabolites, are reported from the Indopacific octocoral Carijoa sp. A strong activity as inhibitors of mitochondrial electron transport system of mammalian cells was found for the new compoun...

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Bibliographic Details
Published inTetrahedron letters Vol. 45; no. 41; pp. 7745 - 7748
Main Authors Ciavatta, M. Letizia, Lopez Gresa, M. Pilar, Manzo, Emiliano, Gavagnin, Margherita, Wahidulla, Solimabi, Cimino, Guido
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 2004
Subjects
Biological activity
Carijoa
Natural substances
Octocoral
Octocoral
Carijoa
Natural substances
Biological activity
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Summary:The isolation and characterization of two new pregnanes (i.e., compound 1 ), together with previously found metabolites, are reported from the Indopacific octocoral Carijoa sp. A strong activity as inhibitors of mitochondrial electron transport system of mammalian cells was found for the new compounds. Two new compounds, pregnanes 1 and 2 , the known pregnane 3 and a series of known chlorinated prostanoids ( 4– 9 ) have been isolated from the Indian octocoral Carijoa sp. Their structures have been elucidated by spectroscopic methods, mainly by 1D and 2D NMR. The new compounds were potent inhibitors of the mitochondrial respiratory chain.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2004.08.061