The curative and antioxidative efficiency of doramectin and doramectin + vitamin AD 3E treatment on Psoroptes cuniculi infestation in rabbits
In the present study, the efficiency of the administration of doramectin (DOR) and DOR + vitamin AD 3E (VIT), and the influence of these agents on oxidative stress parameters in rabbits infested by Psoroptes cuniculi (P. cuniculi) were investigated. DOR (200 μg/kg) and DOR (200 μg/kg) + VIT AD 3E we...
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Published in | Research in veterinary science Vol. 85; no. 2; pp. 291 - 293 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier India Pvt Ltd
2008
|
Subjects | |
Online Access | Get full text |
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Summary: | In the present study, the efficiency of the administration of doramectin (DOR) and DOR
+
vitamin AD
3E (VIT), and the influence of these agents on oxidative stress parameters in rabbits infested by
Psoroptes cuniculi (P. cuniculi) were investigated. DOR (200
μg/kg) and DOR (200
μg/kg)
+
VIT AD
3E were administered to infested rabbits intramuscularly (IM). The administration of DOR and DOR
+
VIT improved the healing of ear lesions on day seven. Increase in the plasma malondialdehyde (MDA) level and erythrocyte catalase (CAT) activity, and decrease in glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities were determined in infested rabbits. In the rabbits which were administered DOR
+
VIT, plasma MDA levels decreased, and erythrocyte GSH-Px and SOD activities increased on day seven. In conclusion, DOR and DOR
+
VIT combination were effective against
P. cunuculi infestation. Infestation stimulated oxidative stress. VIT treatment resulted in antioxidant activity against oxidative stress induced by
P. cuniculi infestation. |
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ISSN: | 0034-5288 1532-2661 |
DOI: | 10.1016/j.rvsc.2007.10.005 |