MANTLE CELL LYMPHOMA IN THE ORAL CAVITY: A RARE CASE REPORT

• Published in: Oral surgery, oral medicine, oral pathology and oral radiology Vol. 137; no. 6; p. e256
• Main Authors: GONÇALVES, Moisés Willian Aparecido, LAVAREZE, Luccas, MACIEL, Tayná Figueiredo, CHONE, Carlos Takahiro, EGAL, Erika Said Abu, ALTEMANI, Albina, MARIANO, Fernanda Viviane
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.06.2024
• ISSN: 2212-4403; 2212-4411
• DOI: 10.1016/j.oooo.2023.12.521

Mantle cell lymphoma (MCL) is a rare subtype of B-cell non-Hodgkin's lymphoma, and its occurrence in the oral cavity is infrequent. A 56-year-old male sought medical attention due to a palate lesion persisting for two years, following a history of trauma while eating. During the medical history interview, the patient disclosed a 50-year history of smoking. Upon physical examination, an asymptomatic nodule with fibroelastic consistency, measuring 2.0 cm, was observed at the midline where the hard and soft palates meet. The lesion displayed erythematous areas and vascular components. An incisional biopsy was performed, and microscopic evaluation revealed a diffuse and monotonous proliferation of small neoplastic cells. These neoplastic cells tested positive for CD3, CD5, CD20, and Cyclin D1, with a Ki-67 index of 15%. Conversely, AE1/AE3, CD34, CD56, c-KIT, TdT, and MPO were negative, further supporting the diagnosis of MCL. The patient was subsequently referred for onco-hematological treatment. Supported by CAPES.