HIV-ASSOCIATED BURKITT LYMPHOMA IN ORAL AND MAXILLOFACIAL REGION: A CASE REPORT

• Published in: Oral surgery, oral medicine, oral pathology and oral radiology Vol. 137; no. 6; p. e172
• Main Authors: da SILVA FILHO, Nilton José, CARDOSO, Diovana de Melo, XAVIER-JÚNIOR, José Cândido Caldeira, CORTOPASSI, Gabriel Macedo, MIYAHARA, Glauco Issamu, BERNABÉ, Daniel Galera, VALENTE, Vitor Bonetti
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.06.2024
• ISSN: 2212-4403; 2212-4411
• DOI: 10.1016/j.oooo.2023.12.121

Burkitt lymphoma (BL), a subtype of B cell non-Hodgkin lymphoma (NHL), is an extremely aggressive neoplastic condition. BL manifests in three distinct variants: endemic, sporadic, and immunodeficiency-associated. A 36-year-old woman who tested positive for HIV was referred for assessment due to extensive mouth swellings that had been developing over the course of three weeks. During the physical examination, facial asymmetry, dysphagia, and difficulties in mouth opening and in the function of her right eye were observed. Intraoral examination revealed painless nodular masses affecting both the maxilla and mandible. Panoramic radiography confirmed involvement of the jaw bones. A biopsy was performed, and microscopic examination revealed an atypical lymphoid infiltrate strongly suggestive of lymphoma. Immunohistochemistry assays yielded positive results for CD20 (L26), CD10 (56C6; 90%), Bcl6 (PG-B6p; 80%), Ki-67 (MIB-1; +95%), and negative results for CD3 (polyclonal), Bcl2 (124), CD30 (Ber-H2), and TDT (EP266). These findings led to the diagnosis of Burkitt lymphoma. The patient was referred for onco-hematological treatment; however, she unfortunately passed away before treatment initiation due to the rapid progression of the disease.