ORAL MALIGNANT MELANOMA ON THE PALATE: CASE REPORT WITH 10 YEARS OF FOLLOW-UP

Oral malignant melanoma (OMM) represents an extremely rare neoplasm. Unlike cutaneous melanomas, the risk factors and pathogenesis of OMM are poorly understood. Here, we report a case of OMM occurring in a 69-year-old female patient. Ten years ago, the patient was referred for evaluation of an exten...

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Published inOral surgery, oral medicine, oral pathology and oral radiology Vol. 137; no. 6; p. e168
Main Authors CORREIA-NETO, Ivan José, CORREA, Marcelo Brum, COLAFEMINA, Ana Carolina Evangelista, ROZA, Ana Luiza Oliveira Corrêa, ELIAS, Rogério de Andrade, VARGAS, Pablo Agustin, LOPES, Márcio Ajudarte
Format Journal Article
LanguageEnglish
Published Elsevier Inc 01.06.2024
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Summary:Oral malignant melanoma (OMM) represents an extremely rare neoplasm. Unlike cutaneous melanomas, the risk factors and pathogenesis of OMM are poorly understood. Here, we report a case of OMM occurring in a 69-year-old female patient. Ten years ago, the patient was referred for evaluation of an extensive, asymptomatic pigmented lesion on the left side of the hard palate, beneath a total prosthesis. An incisional biopsy was performed, and histopathological analysis revealed a variable proliferation of fusiform and pigmented epithelioid cells, exhibiting cellular pleomorphism and a high mitotic index. These cells tested positive for S-100, MelanA, and HMB-45, confirming the diagnosis of OMM. Subsequently, the patient underwent a partial maxillectomy followed by adjuvant radiotherapy. After treatment, she was rehabilitated with a palatal obturator prosthesis and has been under follow-up for 10 years with no evidence of disease recurrence.
ISSN:2212-4403
2212-4411
DOI:10.1016/j.oooo.2023.12.102