1:39 PM Abstract No. 38 - Evaluation of the plasmatic and parenchymal elution kinetics in a domestic pig model using irinotecan-loaded drug-eluting beads

• Published in: Journal of vascular and interventional radiology Vol. 25; no. 3; pp. S23 - S24
• Main Authors: Gnutzmann, D.M., Mechel, J., Schmitz, A., Bellemann, N., Sommer, C., Gockner, T., Mokry, T., Kortes, N., Stampfl, U., Kauczor, H., Radeleff, B.A.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.03.2014
• ISSN: 1051-0443; 1535-7732
• DOI: 10.1016/j.jvir.2013.12.056

Irinotecan is an effective chemotherapeutic agent for local therapy of hepatic metastases caused by colorectal cancer, applied intraarterially by drug-eluting beads (DEB). The severity of systemic side and adverse effects may be linked to different elution kinetics depending on the type of DEB. The purpose of our study was to compare two commercially available types of DEB regarding their elution kinetics by measuring plasma and tissue concentration. 16 domestic pigs were treated by superselective embolization of the left lateral liver lobes with groups of 2 receiving 1 ml either DC Bead®M1 (70-150 µm, DEBIRI®; Biocompatibles, UK) or TANDEM® Microspheres (75 µm, CeloNova, USA) containing each 50 mg Irinotecan. Plasma levels were measured at 0, 10, 20, 30, 60, 120, 180, 240 minutes after completed embolization and at the time of sacrifice (1d, 48h, 72h, 7d for each group, respectively). After sacrifice, samples of approximately 5 grams each were taken for tissue concentration at 3 different sites of the left lateral liver lobe. For the first 4 hours, Irinotecan blood levels were higher in the DEBIRI group than in the TANDEM group. Significant differences were detected at 10 and 20 minutes p.i. with significantly higher Cmax (Median 158.3 ng/mL) in the DEBIRI arm at 10 minutes compared to TANDEM Cmax (Median 90.13 ng/mL) at 20 minutes. No significant difference was found at later time points. AUC for the first 30 minutes was significantly lower for TANDEM. Total AUC showed no significant difference. In the first 4 hours after embolization, Irinotecan is released significantly faster from DEBIRI than from TANDEM Microspheres in a pig model.