Visible-light-promoted CN and CS bonds formation: A catalyst and solvent-free photochemical approach for the synthesis of 1,3-thiazolidin-4-ones

• Published in: Journal of photochemistry and photobiology. A, Chemistry. Vol. 390
• Main Authors: Nazeef, Mohd, Shivhare, Km Neha, Ali, Shabir, Ansari, Khursheed, Ansari, Mohd Danish, Tiwari, Saurabh K., Yadav, Vikas, Siddiqui, I.R.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.03.2020
• Subjects: 1,3-thiazolidin-4-ones; Catalyst and solvent-free protocol; Green synthesis; Mild reaction conditions; Visible-light-induced multicomponent reaction; 1,3-thiazolidin-4-ones; Visible-light-induced multicomponent reaction; Green synthesis; Catalyst and solvent-free protocol; Mild reaction conditions
• ISSN: 1010-6030; 1873-2666
• DOI: 10.1016/j.jphotochem.2019.112347

[Display omitted] •A mild and efficient strategy for the synthesis of 1,3-thiazolidin-4-ones.•22 W CFL (compact fluorescence lamp) is used because of nontoxicity and cost effectiveness.•Catalyst and solvent-free reaction conditions.•Operational simplicity and short reaction durability.•Diversified 4-thiazolidinone scaffolds show numerous biological activities. A visible-light-induced, one-pot mild and efficient, multicomponent-tandem synthesis of diversified 1,3-thiazolidin-4-ones under catalyst and solvent-free conditions is reported. Here, visible-light, an ideal source of energy, has been used as photochemical activator to generate CN and CS bonds under radical mechanistic pathway from aromatic amines, aldehydes and thioglycolic acid. The reported methodology can be extensively utilized to explore 1,3-thiazolidin-4-one derivatives with high selectivity, short reaction time, tolerance of functional groups, cost effectiveness and excellent yields.