Copper-catalyzed three component CS/CN coupling for the synthesis of trifluorothioacetamides

[Display omitted] •A new route to trifluorothioacetamides via copper-catalyzed three component reaction of imines with sulfur and CFC-113a is presented. A copper-catalyzed three component CS/CN coupling reaction of imines with sulfur and CFC-113a was developed. The reaction involves amination and CS...

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Bibliographic Details
Published inJournal of fluorine chemistry Vol. 239
Main Authors Hu, Bo-Lun, Song, Yi-Kang, Zhang, Guoqiang, Yao, Zengwen, Zhang, Xing-Guo
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.11.2020
Subjects
C[sbnd]S/C[sbnd]N coupling
CFC-113a
Copper-catalyzed
Trifluorothioacetamides
Copper-catalyzed
CFC-113a
CS/CN coupling
Trifluorothioacetamides
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Summary:[Display omitted] •A new route to trifluorothioacetamides via copper-catalyzed three component reaction of imines with sulfur and CFC-113a is presented. A copper-catalyzed three component CS/CN coupling reaction of imines with sulfur and CFC-113a was developed. The reaction involves amination and CS double bond formation of CFC-113a, leading to biologically important trifluorothioacetamides. The method features efficient construction of trifluorothioacetyl moiety from cheap sulfur and CFC-113a, and safe disposal for environmentally persistent Freon
ISSN:0022-1139
1873-3328
DOI:10.1016/j.jfluchem.2020.109640