Analgesic effects of the somatostatin sst 4 receptor selective agonist J-2156 in acute and chronic pain models

• Published in: European journal of pharmacology Vol. 539; no. 1; pp. 71 - 75
• Main Authors: Sándor, Katalin, Elekes, Krisztián, Szabó, Árpád, Pintér, Erika, Engström, Mia, Wurster, Siegfried, Szolcsányi, János, Helyes, Zsuzsanna
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 2006
• Subjects: Adjuvant-induced inflammation; Anti-nociceptive effect; Formalin test; Somatostatin; Traumatic mononeuropathy; Adjuvant-induced inflammation; Traumatic mononeuropathy; Somatostatin; Formalin test; Anti-nociceptive effect
• ISSN: 0014-2999; 1879-0712
• DOI: 10.1016/j.ejphar.2006.03.082

Somatostatin released from capsaicin-sensitive afferents exerts systemic anti-nociceptive actions, presumably via somatostatin receptor subtype 4 (sst 4). In the present study, the antinociceptive effects of a novel somatostatin sst 4 receptor selective peptidomimetic compound, J-2156 (1–100 μg/kg i.p.), were examined. J-2156 inhibited nocifensive behaviour of mice in the second phase of the formalin test. Adjuvant-evoked chronic inflammatory mechanical allodynia was decreased in rats treated with J-2156 for 21 days. Sciatic nerve ligation-induced neuropathic mechanical hyperalgesia was inhibited by J-2156 on the seventh postoperative day. Results obtained using this highly selective agonist suggest that somatostatin sst 4 receptors represent a promising target for new perspectives in analgesic therapy.