Novel 3-alkanoyl/aroyl/heteroaroyl-2 H-chromene-2-thiones: Synthesis and evaluation of their antioxidant activities

• Published in: European journal of medicinal chemistry Vol. 45; no. 6; pp. 2250 - 2257
• Main Authors: Singh, Okram Mukherjee, Devi, Nepram Sushuma, Thokchom, Dhanaraj Singh, Sharma, Gurumayum Jitendra
• Format: Journal Article
• Language: English
• Published: Elsevier Masson SAS 2010
• Subjects: Antioxidant; Coumarin; Free radical; Piperidine; β-Oxodithioester; β-Oxodithioester; Piperidine; Antioxidant; Coumarin; Free radical
• ISSN: 0223-5234; 1768-3254
• DOI: 10.1016/j.ejmech.2010.01.070

A facile, convenient and high yielding synthesis of a combinatorial library of 3-alkanoyl/aroyl/heteroaroyl-2 H-chromene-2-thiones has been developed by the condensation of easily accessible β-oxodithioesters and salicylaldehyde/substituted 2-hydroxybenzaldehydes under solvent-free conditions. The assessment of radical scavenging capacity of the compounds towards the stable free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) was measured and these compounds were found to scavenge DPPH free radical efficiently. Five selected compounds were able to protect curcumin from the attack of sulfur free radical generated by radiolysis of glutathione (GSH). The newly synthesized compounds exhibited profound antioxidant activities. Five of them rendered comparatively high antioxidant capacity. A facile synthesis of 3-alkanoyl/aroyl/heteroaroyl-2 H-chromene-2-thiones has been developed by the condensation of easily accessible β-oxodithioesters and salicylaldehyde/substituted 2-hydroxybenzaldehydes under solvent-free conditions. The newly synthesized compounds exhibited profound antioxidant activities. [Display omitted]