ZrO 2-pillared clay: An efficient catalyst for solventless synthesis of biologically active multifunctional dihydropyrimidinones

A novel protocol using ZrO 2-pillared clay (Zr-PILC), prepared by us as a mild recyclable solid acid catalyst for multicomponent one-pot synthesis of dihydropyrimidinones under solvent free conditions both by thermal and microwave heating using the Bronsted and Lewis acidity (proposed mechanism) of...

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Bibliographic Details
Published inCatalysis communications Vol. 7; no. 8; pp. 571 - 578
Main Authors Singh, Vasundhara, Sapehiyia, Varinder, Srivastava, Vivek, Kaur, Sukhbir
Format Journal Article
LanguageEnglish
Published Elsevier B.V 2006
Subjects
monastrol
nitractin
Solventless dihydropyrimidinones
ZrO 2-pillared clay
ZrO 2-pillared clay
MW
nitractin
Solventless dihydropyrimidinones
monastrol
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Summary:A novel protocol using ZrO 2-pillared clay (Zr-PILC), prepared by us as a mild recyclable solid acid catalyst for multicomponent one-pot synthesis of dihydropyrimidinones under solvent free conditions both by thermal and microwave heating using the Bronsted and Lewis acidity (proposed mechanism) of Zr-PILC is reported. The efficacy of the procedure is exemplified by the synthesis of biologically active racemic mixture of monastrol and nitractin (a potent lead anti-cancer drug and antibacterial, antiviral drug, respectively).
ISSN:1566-7367
1873-3905
DOI:10.1016/j.catcom.2005.12.021