pro-NGF, sortilin, and p75 NTR: Potential mediators of injury-induced apoptosis in the mouse dorsal root ganglion
The nerve growth factor precursor (pro-NGF) may function as a death-inducing ligand that mediates its apoptotic effects via p75 NTR. Pro-NGF-induced apoptosis is postulated to be dependent upon membrane expression of the sortilin receptor, which interacts with p75 NTR to promote a high-affinity bind...
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Published in | Brain research Vol. 1183; pp. 32 - 42 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Elsevier B.V
2007
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Subjects | |
Online Access | Get full text |
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Summary: | The nerve growth factor precursor (pro-NGF) may function as a death-inducing ligand that mediates its apoptotic effects via p75
NTR. Pro-NGF-induced apoptosis is postulated to be dependent upon membrane expression of the sortilin receptor, which interacts with p75
NTR to promote a high-affinity binding site for pro-NGF. Here, we explore the expression of pro-NGF, sortilin and p75
NTR in the mouse lumbar dorsal root ganglion (DRG) to understand the potential for this trimeric signaling complex to function in injury-induced neuronal death of DRG neurons. Our results reveal the expression of all 3 components within the DRG and that a subpopulation of neurons coexpresses sortilin and p75
NTR. Following sciatic nerve transection, the expression of these proteins appears insensitive to injury; however, the majority of small p75
NTR–sortilin coexpressing neurons are lost 25 days after sciatic nerve transection. These results propose pro-NGF-induced, p75
NTR–sortilin-mediated neuronal death as a critical aspect of nerve injury-induced death in the DRG. |
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ISSN: | 0006-8993 1872-6240 |
DOI: | 10.1016/j.brainres.2007.09.051 |