Synthesis of N-alkyl glycine amides as potent inhibitors of leukotriene A 4 hydrolase
The synthesis and biological evaluation of a series of N-alkyl glycine amide analogs as LTA 4-h inhibitors and the importance of the introduction of a benzoic acid group to the potency and pharmacokinetic parameters of our analogs are described. The lead compound in the series, 4q, has excellent pot...
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Published in | Bioorganic & medicinal chemistry letters Vol. 18; no. 14; pp. 3891 - 3894 |
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Main Authors | , , , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier Ltd
2008
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Subjects | |
Online Access | Get full text |
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Summary: | The synthesis and biological evaluation of a series of
N-alkyl glycine amide analogs as LTA
4-h inhibitors and the importance of the introduction of a benzoic acid group to the potency and pharmacokinetic parameters of our analogs are described. The lead compound in the series,
4q, has excellent potency and oral bioavailability. |
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ISSN: | 0960-894X 1464-3405 |
DOI: | 10.1016/j.bmcl.2008.06.046 |